gene

HTR3D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR3D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The HTR3D gene encodes the 5-HT3 receptor subunit D, a ligand-gated ion channel component essential for fast serotonergic signaling. This page covers the gene's structure, function, expression, disease associations, and therapeutic relevance.

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🧬 Gene Info

Gene Symbol	HTR3D
Chromosome	3q27.1
Protein Type	Channel
Function	is a member of the ligand-gated ion channel family that forms part of the 5-HT3 receptor.
Primary Expression	specific tissues and form heteromeric receptors with modified properties
Amino Acids	473 aa
Ensembl ID	ENSG00000165644
GeneCards	HTR3D
Human Protein Atlas	HTR3D
HTR3A	Required for functional receptor formation; all functional receptors contain at least one HTR3A subunit
HTR3B	Modulates single-channel conductance and conductance properties
HTR3C/D/E	May be expressed in specific tissues and form heteromeric receptors with modified properties
Single-channel conductance	10-20 pS (varies with subunit composition)
Desensitization	Rapid onset, with recovery on the timescale of seconds
Desensitization kinetics	Modulated by subunit composition, including HTR3D incorporation
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR3D Gene

gene · 1919 words

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Pathway Diagram

graph TD
    HTR3D["HTR3D"]
    neurodegeneration["neurodegeneration"]
    HTR3D -->|"implicated_in"| neurodegeneration
    style HTR3D fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HTR3D in their description or question text

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