| Gene Symbol | HTR3D |
| Chromosome | 3q27.1 |
| Protein Type | Channel |
| Function | is a member of the ligand-gated ion channel family that forms part of the 5-HT3 receptor. |
| Primary Expression | specific tissues and form heteromeric receptors with modified properties |
| Amino Acids | 473 aa |
| Ensembl ID | ENSG00000165644 |
| GeneCards | HTR3D |
| Human Protein Atlas | HTR3D |
| HTR3A | Required for functional receptor formation; all functional receptors contain at least one HTR3A subunit |
| HTR3B | Modulates single-channel conductance and conductance properties |
| HTR3C/D/E | May be expressed in specific tissues and form heteromeric receptors with modified properties |
| Single-channel conductance | 10-20 pS (varies with subunit composition) |
| Desensitization | Rapid onset, with recovery on the timescale of seconds |
| Desensitization kinetics | Modulated by subunit composition, including HTR3D incorporation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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