gene

HTR3A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HTR3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HTR3A Gene

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🧬 Gene Info

Gene Symbol	HTR3A
Chromosome	11q23.2
Protein Type	Channel
Function	The serotonin 3A receptor (5-HT3A) is unique among serotonin receptors as it forms an ion channel rather than coupling to G proteins.
Primary Expression	areas involved in cognition, emesis, and pain processing
Amino Acids	478 aa
Exons	9
Ensembl ID	ENSG00000166736
GeneCards	HTR3A
Human Protein Atlas	HTR3A
Pentameric assembly	Five subunits form a central ion channel pore
N-terminal extracellular domain	Contains the serotonin binding site and characteristic Cys-loop motif
Transmembrane domains (M1-M4)	M2 forms the ion pore
C-terminal extracellular domain	Contains the signature disulfide bond (Cys-loop)
Cytoplasmic loop	Between M3 and M4; determines single-channel properties
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR3A Gene

gene · 810 words

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Pathway Diagram

graph TD
    HTR3A["HTR3A"]
    neurodegeneration["neurodegeneration"]
    HTR3A -->|"implicated_in"| neurodegeneration
    style HTR3A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning HTR3A in their description or question text

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