| Gene Symbol | HTR3A |
| Chromosome | 11q23.2 |
| Protein Type | Channel |
| Function | The serotonin 3A receptor (5-HT3A) is unique among serotonin receptors as it forms an ion channel rather than coupling to G proteins. |
| Primary Expression | areas involved in cognition, emesis, and pain processing |
| Amino Acids | 478 aa |
| Exons | 9 |
| Ensembl ID | ENSG00000166736 |
| GeneCards | HTR3A |
| Human Protein Atlas | HTR3A |
| Pentameric assembly | Five subunits form a central ion channel pore |
| N-terminal extracellular domain | Contains the serotonin binding site and characteristic Cys-loop motif |
| Transmembrane domains (M1-M4) | M2 forms the ion pore |
| C-terminal extracellular domain | Contains the signature disulfide bond (Cys-loop) |
| Cytoplasmic loop | Between M3 and M4; determines single-channel properties |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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