Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HOMER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HOMER2 |
| Full Name | Homer Scaffold Protein 2 |
| Chromosome | 15q24.3 |
| Function | HOMER2 encodes Homer 2, a scaffolding protein that organizes postsynaptic density structures and regulates synaptic signaling. |
| Molecular Weight | 184 kDa |
| Pathways | PI3K, mTOR |
| UniProt ID | [Q9NSC5](https://www.uniprot.org/uniprot/Q9NSC5) |
| Ensembl ID | ENSG00000124827 |
| OMIM | 604869 |
| GeneCards | HOMER2 |
| Human Protein Atlas | HOMER2 |
| EVH1 Domain (N-terminal) | Binds to proline-rich motifs (PPXXF) in target proteins including: |
| Coiled-Coil Domain (C-terminal) | Mediates Homer-Homer multimerization, forming a lattice-like scaffold network |
| Ligand-Binding Domain | Involved in interactions with other synaptic proteins |
| Long-Term Depression (LTD) | mGluR5-HOMER2 signaling is essential for mGluR-LTD |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HOMER2["HOMER2"]
neurodegeneration["neurodegeneration"]
HOMER2 -->|"implicated_in"| neurodegeneration
style HOMER2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HOMER2 in their description or question text
No additional research found