| Gene Symbol | HOMER2 |
| Full Name | Homer Scaffold Protein 2 |
| Chromosome | 15q24.3 |
| Function | HOMER2 encodes Homer 2, a scaffolding protein that organizes postsynaptic density structures and regulates synaptic signaling. |
| Molecular Weight | 184 kDa |
| Pathways | PI3K, mTOR |
| UniProt ID | [Q9NSC5](https://www.uniprot.org/uniprot/Q9NSC5) |
| Ensembl ID | ENSG00000124827 |
| OMIM | 604869 |
| GeneCards | HOMER2 |
| Human Protein Atlas | HOMER2 |
| EVH1 Domain (N-terminal) | Binds to proline-rich motifs (PPXXF) in target proteins including: |
| Coiled-Coil Domain (C-terminal) | Mediates Homer-Homer multimerization, forming a lattice-like scaffold network |
| Ligand-Binding Domain | Involved in interactions with other synaptic proteins |
| Long-Term Depression (LTD) | mGluR5-HOMER2 signaling is essential for mGluR-LTD |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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