gene

HERC4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HERC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

HERC4 is a HECT-type E3 ubiquitin ligase involved in protein ubiquitination, degradation, and cellular quality control. It plays roles in neuroprotection and is implicated in Alzheimer's and Parkinson's disease pathogenesis.

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🧬 Gene Info

Gene Symbol	HERC4
Full Name	HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 4
Chromosome	10q21.3
Protein Type	Ligase
Function	is a member of the HERC family of E3 ubiquitin ligases that play critical roles in protein ubiquitination, cellular signaling, and protein quality control.
Molecular Weight	53 kDa
Amino Acids	475 aa
UniProt ID	Q8N7R4
NCBI Gene ID	26091
Ensembl ID	ENSG00000138641
OMIM	610215
GeneCards	HERC4
Human Protein Atlas	HERC4
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HERC4 — AlphaFold Q8N7R4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HERC4 (HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 4)

gene · 2409 words

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Pathway Diagram

graph TD
    HERC4["HERC4"]
    neurodegeneration["neurodegeneration"]
    HERC4 -->|"implicated_in"| neurodegeneration
    style HERC4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HERC4 in their description or question text

No additional research found