Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GUCY1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GUCY1A1 encodes the alpha subunit of soluble guanylate cyclase, a key enzyme in NO-cGMP signaling that regulates neurovascular function, synaptic plasticity, and is implicated in Alzheimer's and Parkinson's disease pathogenesis.
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| Gene Symbol | GUCY1A1 |
| Full Name | Guanylate Cyclase 1 Soluble Subunit Alpha 1 |
| Chromosome | 4q31.3 |
| Protein Family | Soluble guanylate cyclase subunits (GUCY1A1, GUCY1B1) |
| Function | Soluble guanylate cyclase is activated by |
| Primary Expression | the brain and vascular endothelium, making it a critical nexus for NO-mediated signaling in both physiological and pathological states |
| Amino Acids | 619 aa |
| UniProt ID | Q02108 |
| NCBI Gene ID | 2982 |
| Ensembl ID | ENSG00000147854 |
| OMIM | 139396 |
| GeneCards | GUCY1A1 |
| Human Protein Atlas | GUCY1A1 |
| Heme domain | N-terminal region that binds the heme prosthetic group required for NO sensing (though heme binding is primarily to the β₁ subunit) |
| Dimerization domain | Central region mediates heterodimer formation with GUCY1B1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GUCY1A1["GUCY1A1"]
neurodegeneration["neurodegeneration"]
GUCY1A1 -->|"implicated_in"| neurodegeneration
style GUCY1A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GUCY1A1 in their description or question text
No additional research found