| Gene Symbol | GUCY1A1 |
| Full Name | Guanylate Cyclase 1 Soluble Subunit Alpha 1 |
| Chromosome | 4q31.3 |
| Protein Family | Soluble guanylate cyclase subunits (GUCY1A1, GUCY1B1) |
| Function | Soluble guanylate cyclase is activated by |
| Primary Expression | the brain and vascular endothelium, making it a critical nexus for NO-mediated signaling in both physiological and pathological states |
| Amino Acids | 619 aa |
| UniProt ID | Q02108 |
| NCBI Gene ID | 2982 |
| Ensembl ID | ENSG00000147854 |
| OMIM | 139396 |
| GeneCards | GUCY1A1 |
| Human Protein Atlas | GUCY1A1 |
| Heme domain | N-terminal region that binds the heme prosthetic group required for NO sensing (though heme binding is primarily to the β₁ subunit) |
| Dimerization domain | Central region mediates heterodimer formation with GUCY1B1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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