protein

GRIN2D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIN2D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

3Outgoing

3Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	GRIN2D
Full Name	Glutamate Ionotropic Receptor NMDA Type Subunit 2D
Chromosome	19q13.12
Function	GluN2D-containing NMDA receptors have unique functional properties
Primary Expression	various brainstem nuclei controlling autonomic functions - Cortex: Transient high expression during development, declining in adulthood - Cerebe
Subcellular Localization	</strong></td><td>Postsynaptic density, extrasynaptic membranes</td></tr>
Molecular Weight	175 kDa
Amino Acids	356 aa
Gene Type	Protein coding
UniProt ID	Q9UQF8
NCBI Gene ID	2904
Ensembl ID	ENSG00000182308
GeneCards	GRIN2D
Human Protein Atlas	GRIN2D
Amino-terminal domain (ATD)	Regulates receptor assembly and modulates channel gating. The ATD of GluN2D influences receptor deactivation kinetics and sensitivity to allosteric modulators.
Associated Diseases	neurodegeneration
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GRIN2D — AlphaFold Q9UQF8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["GRIN2D"]
    N1["NMDA"]
    N0 -->|"co expressed with"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein

Outgoing (3)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN2D	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
NMDA	co_expressed_with	protein	0.50

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN2D	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
proteins-grin2d	describes	wiki	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIN2D in their description or question text

No additional research found