Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR87: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GPR87 - a GPCR involved in cellular stress responses and emerging roles in neurodegeneration
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| Gene Symbol | GPR87 |
| Function | GPR87 was originally identified as a G protein-coupled receptor with widespread tissue expression. Early studies characterized it primarily in the context of cancer biology, where overexpression wa... |
| Amino Acids | 358 aa |
| Pathways | MAPK pathway, NF-κB |
| Ensembl ID | ENSG00000138271 |
| GeneCards | GPR87 |
| Human Protein Atlas | GPR87 |
| Transmembrane domains | Seven alpha-helices spanning the membrane |
| Extracellular loops | Three loops involved in ligand binding |
| Intracellular loops | Three loops coupling to G proteins |
| C-terminal tail | Contains phosphorylation sites for desensitization |
| G protein coupling domain | Located in intracellular loop 2 |
| Ligand binding pocket | Formed by transmembrane domains 3-7 |
| Dimerization interface | Can form homodimers and heterodimers |
| High expression | Skin, lung, kidney, urinary bladder |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GPR87["GPR87"]
neurodegeneration["neurodegeneration"]
GPR87 -->|"implicated_in"| neurodegeneration
style GPR87 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPR87 in their description or question text
No additional research found