| Gene Symbol | GPR87 |
| Function | GPR87 was originally identified as a G protein-coupled receptor with widespread tissue expression. Early studies characterized it primarily in the context of cancer biology, where overexpression wa... |
| Amino Acids | 358 aa |
| Pathways | MAPK pathway, NF-κB |
| Ensembl ID | ENSG00000138271 |
| GeneCards | GPR87 |
| Human Protein Atlas | GPR87 |
| Transmembrane domains | Seven alpha-helices spanning the membrane |
| Extracellular loops | Three loops involved in ligand binding |
| Intracellular loops | Three loops coupling to G proteins |
| C-terminal tail | Contains phosphorylation sites for desensitization |
| G protein coupling domain | Located in intracellular loop 2 |
| Ligand binding pocket | Formed by transmembrane domains 3-7 |
| Dimerization interface | Can form homodimers and heterodimers |
| High expression | Skin, lung, kidney, urinary bladder |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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