Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPHN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GPHN |
| Full Name | Gephyrin |
| Chromosome | 14q23.3 |
| Protein Type | Scaffold Protein |
| Function | Gephyrin is a 93 kDa protein that forms a hexagonal lattice at inhibitory synapses |
| Molecular Weight | 93 kDa |
| UniProt ID | Q9NQB0 |
| NCBI Gene ID | 10253 |
| Ensembl ID | ENSG00000170950 |
| GeneCards | GPHN |
| Human Protein Atlas | GPHN |
| Receptor clustering | organizes GlyR and GABA<sub>A</sub> receptor clusters |
| Synaptic plasticity | modulates inhibitory synaptic strength |
| Cytoskeletal anchoring | links receptors to the actin cytoskeleton |
| GABA synthesis | contains domains for molybdenum cofactor synthesis |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GPHN["GPHN"]
style GPHN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
inhibitory_neurons(["inhibitory neurons"])
GABA["GABA"]
neurodegeneration["neurodegeneration"]
GPHN -->|"expressed_in"| inhibitory_neurons
GABA -->|"expressed_in"| GPHN
GPHN -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class inhibitory_neurons protein
class GABA gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| inhibitory neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GABA | expressed_in | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPHN in their description or question text
No additional research found