gene

GIGYF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GIGYF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for GIGYF2 — GRB10 Interacting GYF Protein 2

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🧬 Gene Info

Gene Symbol	GIGYF2
Full Name	GRB10 Interacting GYF Protein 2
Aliases	GRB10-Interacting GYF Protein 2
Chromosome	5q33.21.
Protein Family	GYF domain family, adaptor proteins
Protein Type	Adaptor Protein
Molecular Weight	270 kDa
Amino Acids	443 aa
Pathways	PI3K, MAPK, signaling: \| Function \| Mechanism \|
UniProt ID	Q9UHQ2
NCBI Gene ID	26060
GeneCards	GIGYF2
Human Protein Atlas	GIGYF2
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GIGYF2 — AlphaFold Q9UHQ2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GIGYF2["GIGYF2 Gene"]
    
    GIGYF2 -->|"encodes"| GIGYF2_PROTEIN["GIGYF2 Protein"]
    GIGYF2_PROTEIN -->|"binds to"| GRB10["GRB10 Adapter Protein"]
    GIGYF2_PROTEIN -->|"interacts with"| 4EBP1["4E-BP1"]
    
    GIGYF2_PROTEIN -->|"regulates"| TRANSLATION_INIT["Translation Initiation"]
    TRANSLATION_INIT -->|"controls"| PROTEIN_SYNTHESIS["Protein Synthesis"]
    
    GIGYF2_PROTEIN -->|"modulates"| INSULIN_SIGNALING["Insulin/IGF-1 Signaling"]
    INSULIN_SIGNALING -->|"affects"| MTOR_PATHWAY["mTOR Pathway"]
    MTOR_PATHWAY -->|"regulates"| AUTOPHAGY["Autophagy"]
    
    GIGYF2 -->|"modulates"| ENDOTHELIAL_SENESCENCE["Endothelial Cell Senescence"]
    ENDOTHELIAL_SENESCENCE -->|"impairs"| BBB_FUNCTION["Blood-Brain Barrier Function"]
    BBB_FUNCTION -->|"leads to"| NEUROINFLAMMATION["Neuroinflammation"]
    
    AUTOPHAGY -->|"clears"| PROTEIN_AGGREGATES["Protein Aggregates"]
    NEUROINFLAMMATION -->|"promotes"| NEURONAL_DEATH["Neuronal Death"]
    PROTEIN_AGGREGATES -->|"accumulate in"| NEURODEGENERATION["Neurodegeneration"]
    NEURONAL_DEATH -->|"contributes to"| NEURODEGENERATION
    
    GIGYF2_PROTEIN -->|"dysfunction leads to"| PARKINSONS["Parkinson's Disease"]
    PARKINSONS -->|"characterized by"| NEURODEGENERATION

    style GIGYF2 fill:#1a3a4a,stroke:#4fc3f7
    style GIGYF2_PROTEIN fill:#2a1a3a,stroke:#ce93d8
    style AUTOPHAGY fill:#1a3a2a,stroke:#81c784
    style PROTEIN_SYNTHESIS fill:#1a3a2a,stroke:#81c784
    style ENDOTHELIAL_SENESCENCE fill:#3a1a1a,stroke:#ef5350
    style NEUROINFLAMMATION fill:#3a1a1a,stroke:#ef5350
    style NEURONAL_DEATH fill:#3a1a1a,stroke:#ef5350
    style NEURODEGENERATION fill:#3a2a1a,stroke:#ffa726
    style PARKINSONS fill:#3a2a1a,stroke:#ffa726

Outgoing (1)

Target	Relation	Type	Str
Endothelial Cell Senescence	modulates	biological_process	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GIGYF2 in their description or question text

No additional research found