gene

GCAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

3Outgoing

1Incoming

0Experiments

0Debates

Summary

Comprehensive overview of GCAT (glycerol-3-phosphate O-acetyltransferase), a mitochondrial enzyme in glycerolipid biosynthesis with implications for Alzheimer's Disease, Parkinson's Disease, and metabolic disorders.

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🧬 Gene Info

Gene Symbol	GCAT
Full Name	Glycerol-3-Phosphate O-Acetyltransferase
Chromosome	22q13.33
Protein Type	Enzyme
Function	encodes a mitochondrial enzyme that catalyzes the initial committed step in glycerolipid biosynthesis—the acylation of glycerol-3-phosphate to form lysophosphatidic acid (LPA)[@leung2004][@takeuchi...
Amino Acids	471 aa
Exons	9
UniProt ID	Q9Y5K8
NCBI Gene ID	55324
Ensembl ID	ENSG00000128283
OMIM	608807
GeneCards	GCAT
Human Protein Atlas	GCAT
Associated Diseases	Aging, Als
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GCAT — AlphaFold Q9Y5K8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GCAT — Glycerol-3-Phosphate O-Acetyltransferase

gene · 1359 words

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Pathway Diagram

graph TD
    GCAT["GCAT"]
    Als{"Als"}
    GCAT -->|"associated with"| Als
    Aging{"Aging"}
    GCAT -->|"associated with"| Aging
    OTOF["OTOF"]
    GCAT -->|"associated with"| OTOF
    neurodegeneration["neurodegeneration"]
    GCAT -->|"implicated in"| neurodegeneration
    SNAP29["SNAP29"]
    SNAP29 -->|"associated with"| GCAT
    style GCAT fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
OTOF	associated_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
SNAP29	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GCAT in their description or question text

No additional research found