entity

Fe

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Fe: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections
30Hypotheses
1Analyses
2Outgoing
0Incoming
5Experiments
1Debates

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Wiki Pages (20)

Knowledge base pages for this entity

Ferroptosis in Alzheimer's Disease

mechanism · 4194 words

Ferroptosis in Neurodegeneration

mechanism · 3536 words

Ferroptotic Neurons

cell · 3288 words

PSP Ferroptosis and Iron-Dependent Cell Death

mechanism · 2954 words

Fear Conditioning

mechanism · 2929 words

Outgoing (2)

TargetRelationTypeStr
Phospholipid Peroxidationcausesprocess0.95
Substantia Nigraassociated_withbrain_region0.90

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro 0.891 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport F 0.851 ALS -
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec 0.843 neurodegeneration How do different microglial subtypes (DA
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio 0.838 neurodegeneration View
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt 0.824 neurodegeneration View
GLE1-Mediated mRNA Export Defect Creates Translation-Compete 0.823 ALS -
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy 0.812 neurodegeneration View
Thalamocortical Feedforward Inhibition Imposes Rhythm on Gly 0.808 neuroscience GluN2B-Mediated Thalamocortical Control
Targeting the Mechanistic Link Between AQP4 Dysfunction and 0.803 neurodegeneration View
MATR3 Nuclear Body Disruption Impairs RNA Processing Hubs an 0.801 ALS -
Gamma entrainment repairs cross-regional phase-amplitude cou 0.801 Alzheimer's disease Gamma entrainment therapy to restore hip
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive 0.801 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri 0.801 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep 0.800 neurodegeneration Blood-brain barrier antibody transport m
Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective 0.798 neurodegeneration View
Closed-loop transcranial focused ultrasound targeting CA1 PV 0.797 Alzheimer's disease Circuit-level neural dynamics in neurode
Targeting SASP-Complement Amplification Through HIF-1α Downs 0.793 neurodegeneration What molecular mechanism causes VCP muta
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi 0.783 neurodegeneration -
Differential Complement Regulator Expression on Synaptic Mem 0.783 synaptic biology What determines the selectivity of compl
TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis 0.779 neurodegeneration What molecular mechanism causes VCP muta
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo 0.779 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop 0.777 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub 0.776 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v 0.772 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul 0.764 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
Iron-driven lipid peroxidation and GPX4 failure create a fer 0.750 neurodegeneration What mechanisms drive the self-amplifyin
HSP90-cochaperone complexes preferentially stabilize interme 0.000 protein biochemistry Do chaperones selectively recognize path
LAMP1 Overexpression to Enhance Lysosomal Capacity Independe 0.000 proteomics Quantitative proteomics of the aging syn
CREB-Dependent Differential Complement Regulator Positioning 0.000 synaptic biology What determines the selectivity of compl
Cell-Type-Specific TFEB Modulation Combined with Trehalose f 0.000 proteomics Quantitative proteomics of the aging syn

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Experiments (5)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice validation Alzheimer's disease 0.900 0.00 5xFAD transgenic mice proposed N/A
Transcriptomic profiling and differential expression analysis exploratory Alzheimer's disease 0.900 0.00 1-month-old APP/PS1 mice cereb proposed N/A
Irisin effects on osteogenic differentiation in mesenchymal stem cells exploratory bone fracture 0.900 0.00 mouse bone mesenchymal stem ce proposed N/A
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State in_vivo neurodegeneration 0.774 0.65 C57BL/6J LPS model (chronic i. proposed $58,000
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat in_vivo post-cardiac-arrest neurodegen 0.768 0.72 Sprague-Dawley rat asphyxial c abandoned $48,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] Jorstad NL, Close J, Johansen N, Yanny A Science 2023 186
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445] Qin J, Ma S, Wang J, Huang S, Luan J, He Cell death & disease 2026 0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795] Gao C, Liu B, Zhang R, Tian J, Xin H Toxicology mechanisms and meth 2026 0
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] Albrechtsen HM, Saritas G, Winge SB, Mai J Clin Endocrinol Metab 2026 0
Epigenetics in chronic rhinosinusitis. [PMID:41442742] Kumar N, Brar T, Lal D Curr Opin Otolaryngol Head Nec 2026 0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890] Rao W, Huang Y, Li J, Chen Q, Sun J et a J Stroke Cerebrovasc Dis 2026 0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] Lin D, Li K, Kuang W, Chen Z, Zhang M World J Mens Health 2026 0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496] Che L, Zhu L, Zhou L, Zhou Y Biochim Biophys Acta Rev Cance 2026 0
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085] Wen H, Zi Y, Liu Z, Bai Y, Lin J et al. Cell Death Differ 2026 0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] Jackson G, Islam H, de Souza Teixeira AA Life Sci 2026 0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570] Chien Y, Xia R, Zhou D, Ai Y, Wu L et al Hepatol Commun 2026 0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] Mishra R, Gupta JK Curr Alzheimer Res 2026 0
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462] Tan Y, Ye H, Ge Q, Wang P, Liu Z et al. J Magn Reson Imaging 2026 0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] Gu X, Sun F, Li Y, Yang S, Li Y Int J Biol Macromol 2026 0
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] Pavlović N, Todorović P, Maglica M, Kopi Int J Mol Sci 2026 0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558] Singh P, Rath SL Journal of Alzheimer's disease 2026 0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334] Song C, Wu X, Chen C, Shen B, He Y, Liu Drug design, development and t 2026 0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] ["Xin R", "Zhang J", "Zhang Y", "Dai M", Free radical biology & medicin 2026 0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086] Wang Y, Zhang W, Zhang M, Zhu Y, Wang W, Tissue & cell 2026 0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] Mishra R, Gupta JK Current Alzheimer research 2026 0

Debates (1)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

Related Research

Hypotheses and analyses mentioning Fe in their description or question text

SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent N

Score: 0.812 · neurodegeneration · 2026-04-17

## Mechanistic Overview SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endo

Thalamocortical Feedforward Inhibition Imposes Rhythm on Glymphatic Waste Cleara

Score: 0.808 · neuroscience · 2026-04-28

Thalamic ventrobasal nucleus GluN2B-mediated burst firing entrains cortical slow-wave oscillations (0.5-1 Hz) during NRE

Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents

Score: 0.803 · neurodegeneration · 2026-04-17

## Mechanistic Overview Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic

Gamma entrainment repairs cross-regional phase-amplitude coupling via CA1 Schaff

Score: 0.801 · Alzheimer's disease · 2026-04-28

Auditory 40 Hz entrainment applied during NREM sleep consolidates temporal coupling between hippocampal theta oscillatio

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

Score: 0.801 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzhe

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

Score: 0.801 · Alzheimer's Disease · 2026-04-05

## Mechanistic Overview 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Diseas

pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery

Score: 0.800 · neurodegeneration · 2026-04-22

## Mechanistic Overview pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery starts from the

Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector

Score: 0.798 · neurodegeneration · 2026-04-17

## Mechanistic Overview Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector starts from the claim that

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Score: 0.797 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f

Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors

Score: 0.793 · neurodegeneration · 2026-04-14

## Mechanistic Overview Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors starts from the clai

Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46)

Score: 0.783 · synaptic biology · 2026-04-21

**Molecular Mechanism and Rationale** The differential expression of complement regulators CD55 (decay-accelerating fac

TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis

Score: 0.779 · neurodegeneration · 2026-04-14

## Mechanistic Overview TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis starts from the claim that modulating