Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | FER2 |
| Function | encodes a mitochondrial protein belonging to the ferredoxin family of iron-sulfur (Fe-S) proteins. |
| Primary Expression | steroidogenic tissues - FDX2 (Ferredoxin 2): Mitochondrial ferredoxin with overlapping functions - FDX1L (Ferredoxin 1-like): A truncated vari |
| Subcellular Localization | to mitochondria where it plays a critical role in [iro |
| Amino Acids | 120 aa |
| Ensembl ID | ENSG00000140497 |
| GeneCards | FER2 |
| Human Protein Atlas | FER2 |
| Conserved 2Fe-2S cluster binding domain | The signature region containing four conserved cysteine residues (Cys-X4-Cys-X2-Cys-X5-Cys motif) that ligate the iron-sulfur cluster |
| C-terminal acidic domain | A regionrich in acidic residues involved in protein-protein interactions |
| FDX1 (Ferredoxin 1) | Predominantly expressed in steroidogenic tissues |
| FDX2 (Ferredoxin 2) | Mitochondrial ferredoxin with overlapping functions |
| FDX1L (Ferredoxin 1-like) | A truncated variant |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FER2["FER2"]
neurodegeneration["neurodegeneration"]
FER2 -->|"implicated_in"| neurodegeneration
style FER2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FER2 in their description or question text
No additional research found