gene

FCGR2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FCGR2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

1Analyses

0Outgoing

1Incoming

0Experiments

2Debates

Summary

Fc gamma receptor IIa (FCGR2A)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FCGR2A
Chromosome	1q23.3
Protein Type	Receptor
Function	FCGR2A encodes a transmembrane glycoprotein receptor that binds the Fc region of IgG antibodies.
GeneCards	FCGR2A
Human Protein Atlas	FCGR2A
Activating isoform	Contains an immunoreceptor tyrosine-based activation motif (ITAM) in the associated FcR γ chain
Inhibitory isoform	Contains an immunoreceptor tyrosine-based inhibition motif (ITAM) that can mediate inhibitory signals
Phagocytosis	Engulfment of IgG-opsonized particles
ADCC	Destruction of antibody-coated target cells
Cytokine release	Production of TNF-α, IL-1β, IL-6, and other inflammatory mediators
Antigen presentation	Processing and presentation of captured antigens to T cells[@nimmerjahn2008]
R131 (high-affinity)	Associated with increased microglial activation and potentially higher AD risk
H131 (low-affinity)	May confer protection through reduced chronic inflammation[@huang2017]
Chronic neuroinflammation	Persistent microglial activation leading to neuronal damage
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Fc gamma receptor IIa (FCGR2A)

gene · 802 words

→

Pathway Diagram

graph TD
    FCGR2A["FCGR2A"]
    IGG(["IGG"])
    AKT(["AKT"])
    Monoclonal_Antibodies{"Monoclonal Antibodies"}
    neurodegeneration["neurodegeneration"]

    IGG -->|"binds"| FCGR2A
    FCGR2A -->|"activates"| AKT
    Monoclonal_Antibodies -->|"interacts with"| FCGR2A
    FCGR2A -->|"implicated in"| neurodegeneration

    style FCGR2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style IGG fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style AKT fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style Monoclonal_Antibodies fill:#1a3a3a,stroke:#4dd0e1,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
ALKB	related_to	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning FCGR2A in their description or question text

No additional research found