gene

ELP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for ELP1 — Elongator Complex Subunit 1

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🧬 Gene Info

Gene Symbol	ELP1
Full Name	Elongator Complex Subunit 1
Chromosome	6p21.31
Function	Elongator Complex Subunit 1 (ELP1), also known as IKBKAP (IKK complex-associated protein), is a scaffolding protein that is part of the Elongator complex
Molecular Weight	~140 kDa
Amino Acids	238 aa
GeneCards	ELP1
Human Protein Atlas	ELP1
Transcription elongation	Elongator facilitates RNA polymerase II transcription through chromatin
Histone acetylation	The complex has histone acetyltransferase (HAT) activity, primarily through ELP3
tRNA modification	Elongator modifies uridine at wobble positions in tRNAs (uridine 34), affecting translation accuracy
Cytoskeletal organization	ELP1 is involved in actin cytoskeleton dynamics
Neuronal function	Elongator is particularly important in neurons, affecting dendritic arborization and axon guidance
Associated Diseases	neurodegeneration
Interactions	Elongator
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ELP1 — Elongator Complex Subunit 1

gene · 653 words

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Pathway Diagram

flowchart TD
    N0["ELP1"]
    N1["Elongator"]
    N1 -->|"interacts with"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
Elongator	interacts_with	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ELP1 in their description or question text

No additional research found