gene

EEF1G

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about EEF1G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for EEF1G — Eukaryotic Translation Elongation Factor 1 Gamma

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🧬 Gene Info

Gene Symbol	EEF1G
Full Name	Eukaryotic Translation Elongation Factor 1 Gamma
Chromosome	11q12.3
Function	is a critical subunit of the eukaryotic translation elongation factor 1 (EF-1) complex, which is essential for protein synthesis in all eukaryotic cells.
Primary Expression	various cancers, highlighting its importance in cell proliferation and survival[@edmunds2002]
Amino Acids	437 aa
Ensembl ID	ENSG00000185208
GeneCards	EEF1G
Human Protein Atlas	EEF1G
Cytoskeletal interactions	Associates with microtubules and actin filaments
Signal transduction	Involved in cellular signaling pathways
Dysregulated expression	Altered EEF1G levels in motor neurons of ALS patients
Stress granule formation	Participates in stress granule dynamics, which are disrupted in ALS
Protein homeostasis	Essential for maintaining proper translation under cellular stress
TDP-43 pathology	Interaction with TDP-43 protein aggregates
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EEF1G — Eukaryotic Translation Elongation Factor 1 Gamma

gene · 737 words

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Pathway Diagram

graph TD
    EEF1G["EEF1G"]
    neurodegeneration["neurodegeneration"]
    EEF1G -->|"implicated_in"| neurodegeneration
    style EEF1G fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning EEF1G in their description or question text

No additional research found