gene

DYNC1LI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNC1LI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	DYNC1LI1
Full Name	Dynein Cytoplasmic 1 Light Intermediate Chain 1
Chromosome	3p21.31
Function	encodes a critical subunit of the cytoplasmic dynein-1 complex, the primary minus-end-directed microtubule motor responsible for intracellular retrograde transport in eukaryotic cells.
Molecular Weight	57 kDa
Amino Acids	523 aa
Exons	17
Ensembl ID	ENSG00000136240
GeneCards	DYNC1LI1
Human Protein Atlas	DYNC1LI1
Isoform 1	Full-length (523 aa) — predominant in neurons
Isoform 2	Truncated (480 aa) — testis-specific
Isoform 3	Alternative N-terminus — tissue-specific
Step size	~8-16 nm per ATP hydrolysis
Velocity	~0.5-1 μm/s in vivo
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DYNC1LI1 — Dynein Cytoplasmic 1 Light Intermediate Chain 1

gene · 2059 words

→

DYNC1LI1 Protein

protein · 1909 words

→

Pathway Diagram

graph TD
    DYNC1LI1["DYNC1LI1"]
    neurodegeneration["neurodegeneration"]
    DYNC1LI1 -->|"implicated_in"| neurodegeneration
    style DYNC1LI1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DYNC1LI1 in their description or question text

No additional research found