| Gene Symbol | DYNC1LI1 |
| Full Name | Dynein Cytoplasmic 1 Light Intermediate Chain 1 |
| Chromosome | 3p21.31 |
| Function | encodes a critical subunit of the cytoplasmic dynein-1 complex, the primary minus-end-directed microtubule motor responsible for intracellular retrograde transport in eukaryotic cells. |
| Molecular Weight | 57 kDa |
| Amino Acids | 523 aa |
| Exons | 17 |
| Ensembl ID | ENSG00000136240 |
| GeneCards | DYNC1LI1 |
| Human Protein Atlas | DYNC1LI1 |
| Isoform 1 | Full-length (523 aa) — predominant in neurons |
| Isoform 2 | Truncated (480 aa) — testis-specific |
| Isoform 3 | Alternative N-terminus — tissue-specific |
| Step size | ~8-16 nm per ATP hydrolysis |
| Velocity | ~0.5-1 μm/s in vivo |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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