gene

DYNC1H1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNC1H1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: DYNC1H1

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🧬 Gene Info

Gene Symbol	DYNC1H1
Full Name	Dynein Cytoplasmic 1 Heavy Chain 1
Chromosome	14q32.31
Function	Dynein transports diverse cargo including mitochondria, endosomes, lysosomes, signaling endosomes, and mRNA granules from the distal axon back toward the cell body (retrograde transport).
Primary Expression	Motor neurons, Cerebral cortex, Widespread
Molecular Weight	532 kDa
UniProt ID	Q14204
NCBI Gene ID	1778
Ensembl ID	ENSG00000197958
OMIM	600112
GeneCards	DYNC1H1
Human Protein Atlas	DYNC1H1
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYNC1H1 — AlphaFold Q14204 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DYNC1H1 — Dynein Cytoplasmic 1 Heavy Chain 1

gene · 1188 words

→

DYNC1H1 Protein

protein · 765 words

→

Pathway Diagram

graph TD
    DYNC1H1["DYNC1H1"]
    neurodegeneration["neurodegeneration"]
    DYNC1H1 -->|"implicated_in"| neurodegeneration
    style DYNC1H1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DYNC1H1 in their description or question text

No additional research found