concept

DUBS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUBS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

1Analyses

3Outgoing

3Incoming

0Experiments

1Debates

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💡 Concept Info

Name	DUBS
Related Diseases	OXIDATIVE_STRESS, ROS
Related Pathways	OXIDATIVE_STRESS_RESPONSE, REDOX_REGULATION, UBIQUITIN_SIGNALING

Pathway Diagram

graph TD
    DUBS["DUBS"]
    DUBS -->|"regulates"| Ubiquitin_Signaling["Ubiquitin Signaling"]
    DUBS -->|"cleaves"| UBIQUITIN["UBIQUITIN"]
    DUBS -->|"inhibits"| UBIQUITIN_CONJUGASES["UBIQUITIN CONJUGASES"]
    DUBS -->|"modulates"| Protein_Activity["Protein Activity"]
    DUBS -->|"regulates"| Protein_Stability["Protein Stability"]
    DUBS -->|"regulates"| Protein_Localization["Protein Localization"]
    DUBS -->|"regulates"| Ubiquitination["Ubiquitination"]
    DUBS -->|"regulates"| UBIQUITIN_SIGNALING["UBIQUITIN_SIGNALING"]
    Reactive_Oxygen_Species["Reactive Oxygen Species"] -->|"modulates"| DUBS
    Protein_Protein_Interaction["Protein-Protein Interaction"] -->|"regulates"| DUBS
    Posttranslational_Modification["Posttranslational Modification"] -->|"regulates"| DUBS
    ROS["ROS"] -->|"regulates"| DUBS
    OXIDATIVE_STRESS["OXIDATIVE_STRESS"] -->|"regulates"| DUBS
    REDOX_REGULATION["REDOX_REGULATION"] -->|"regulates"| DUBS

Outgoing (3)

Target	Relation	Type	Str
UBIQUITIN_SIGNALING	regulates	pathway	0.72
K63-Ub turnover on stress granule proteins	regulates	process	0.70
OXIDATIVE_STRESS_RESPONSE	participates_in	pathway	0.64

Incoming (3)

Source	Relation	Type	Str
ROS	regulates	phenotype	0.64
OXIDATIVE_STRESS	regulates	phenotype	0.64
REDOX_REGULATION	regulates	pathway	0.64

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

closed · Rounds: 4 · Score: 0.79 · 2026-04-21

Related Research

Hypotheses and analyses mentioning DUBS in their description or question text

No additional research found