gene

DRD5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DRD5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	DRD5
Aliases	D5 Dopamine Receptor
Chromosome	4p15.1
Function	Drd5 Protein (D5 Dopamine Receptor) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in d...
Molecular Weight	53 kDa
Ensembl ID	ENSG00000169679
GeneCards	DRD5
Human Protein Atlas	DRD5
Primates	Near-identical protein sequences
Rodents	95% amino acid homology with humans
Fish	Functional orthologs identified
Basal signaling	~30-40% of maximal activation without ligand
Stability	Mutations can further increase constitutive activity
Implications	Continuous Gs coupling even at low dopamine levels
Third intracellular loop	Different length and composition
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DRD5["DRD5"]
    neurodegeneration["neurodegeneration"]
    DRD5 -->|"implicated_in"| neurodegeneration
    style DRD5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DRD5 in their description or question text

No additional research found