| Gene Symbol | DRD5 |
| Aliases | D5 Dopamine Receptor |
| Chromosome | 4p15.1 |
| Function | Drd5 Protein (D5 Dopamine Receptor) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in d... |
| Molecular Weight | 53 kDa |
| Ensembl ID | ENSG00000169679 |
| GeneCards | DRD5 |
| Human Protein Atlas | DRD5 |
| Primates | Near-identical protein sequences |
| Rodents | 95% amino acid homology with humans |
| Fish | Functional orthologs identified |
| Basal signaling | ~30-40% of maximal activation without ligand |
| Stability | Mutations can further increase constitutive activity |
| Implications | Continuous Gs coupling even at low dopamine levels |
| Third intracellular loop | Different length and composition |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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