Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DNAJC16 |
| Protein Family | DnaJ/Hsp40 Family |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cytoplasm, Mitochondria, Endoplasmic Reticulum |
| Molecular Weight | 42 kDa |
| Amino Acids | 382 aa |
| UniProt ID | [Q9H0U4](https://www.uniprot.org/uniprot/Q9H0U4) |
| GeneCards | DNAJC16 |
| Human Protein Atlas | DNAJC16 |
| Glycine/phenylalanine-rich region | A flexible linker region between the J domain and C-terminal regions that facilitates protein-protein interactions and may contain serine phosphorylation sites. |
| C-terminal client-binding domain | Contains regions predicted to form coiled-coil structures that recognize and bind unfolded or misfolded client proteins. |
| Central nervous system | High expression in brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum. Expression is detected in both neuronal and glial cell populations. |
| Peripheral tissues | Moderate expression in heart, skeletal muscle, liver, and kidney. |
| Cellular localization | Cytosolic localization with potential association with membrane compartments and organelles involved in protein quality control, including the endoplasmic reticulum and mitochondria. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC16["DNAJC16"]
autophagosome["autophagosome"]
autophagy["autophagy"]
neurodegeneration["neurodegeneration"]
DNAJC16 -->|"associated with"| autophagosome
DNAJC16 -->|"participates in"| autophagy
DNAJC16 -->|"implicated in"| neurodegeneration
style DNAJC16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style autophagosome fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
style autophagy fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJC16 in their description or question text
No additional research found