protein

DLGAP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLGAP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DLGAP3 (SAPAP3) is a postsynaptic density protein critical for synaptic scaffolding, receptor anchoring, and plasticity. This comprehensive page covers its structure, normal neuronal function, role in neurodegenerative diseases, and therapeutic potential.

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🔬 Protein Info

Gene Symbol	DLGAP3
Aliases	SAPAP3
Chromosome	19p13.3
Function	DLGAP3 (SAPAP3) is a postsynaptic density protein that plays a crucial role in excitatory synaptic transmission and plasticity.
Primary Expression	the brain, particularly in: - Cerebral cortex - Hippocampus - Striatum - [Cerebellum](/brain-
Molecular Weight	109 kDa
Amino Acids	854 aa
UniProt ID	O75180
NCBI Gene ID	58524
Ensembl ID	ENSG00000153779
GeneCards	DLGAP3
Human Protein Atlas	DLGAP3
Autism Spectrum Disorder	Rare variants in DLGAP3 have been identified in patients with ASD.
Intellectual Disability	Loss-of-function mutations contribute to intellectual disability phenotypes.
Obsessive-Compulsive Disorder	DLGAP3 (particularly SAPAP3/DLGAP3) has been linked to OCD-like behaviors in mouse models.
Associated Diseases	Autism Spectrum Disorder
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DLGAP3 — AlphaFold O75180 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DLGAP3 Gene

gene · 575 words

→

DLGAP3 Protein

protein · 2095 words

→

Pathway Diagram

graph TD
    DLGAP3["DLGAP3"]
    neurodegeneration["neurodegeneration"]
    DLGAP3 -->|"implicated in"| neurodegeneration
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    DLGAP3 -->|"implicated in"| Neurodegenerative_Diseases
    style DLGAP3 fill:#1a4a3a,stroke:#81c784,stroke-width:3px,color:#fff
    style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLGAP3 in their description or question text

No additional research found