| Gene Symbol | DLGAP3 |
| Aliases | SAPAP3 |
| Chromosome | 19p13.3 |
| Function | DLGAP3 (SAPAP3) is a postsynaptic density protein that plays a crucial role in excitatory synaptic transmission and plasticity. |
| Primary Expression | the brain, particularly in: - Cerebral cortex - Hippocampus - Striatum - [Cerebellum](/brain- |
| Molecular Weight | 109 kDa |
| Amino Acids | 854 aa |
| UniProt ID | O75180 |
| NCBI Gene ID | 58524 |
| Ensembl ID | ENSG00000153779 |
| GeneCards | DLGAP3 |
| Human Protein Atlas | DLGAP3 |
| Autism Spectrum Disorder | Rare variants in DLGAP3 have been identified in patients with ASD. |
| Intellectual Disability | Loss-of-function mutations contribute to intellectual disability phenotypes. |
| Obsessive-Compulsive Disorder | DLGAP3 (particularly SAPAP3/DLGAP3) has been linked to OCD-like behaviors in mouse models. |
| Associated Diseases | Autism Spectrum Disorder |
| Databases | GeneCardsHPASTRING |
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