Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DAGLB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DAGLB encodes diacylglycerol lipase beta, the enzyme that produces 2-AG, a major endocannabinoid neurotransmitter in the brain.
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| Gene Symbol | DAGLB |
| Full Name | Diacylglycerol Lipase Beta |
| Chromosome | 7q31.1 |
| Protein Type | Enzyme |
| Function | is a membrane-bound enzyme that catalyzes the hydrolysis of diacylglycerol to produce 2-AG[@stella1997]. |
| Primary Expression | brain regions involved in learning, memory, and motor control, including the hippocampus, [cortex](/brain-regions/cortex |
| Amino Acids | 672 aa |
| UniProt ID | Q8WWS3 |
| NCBI Gene ID | 27143 |
| Ensembl ID | ENSG00000153048 |
| GeneCards | DAGLB |
| Human Protein Atlas | DAGLB |
| Substrate specificity | Prefers sn-1,2-diacylglycerols with arachidonoyl (20:4) fatty acid chains |
| Regional distribution | Highest activity in the cerebellum, hippocampus, and prefrontal cortex |
| Cellular localization | Enriched in postsynaptic dendritic spines |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["DAGLB"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning DAGLB in their description or question text
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