gene

DAGLA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAGLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DAGLA is the primary biosynthetic enzyme for 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid in the brain, playing crucial roles in synaptic transmission, neuroprotection, and motor control.

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🧬 Gene Info

Gene Symbol	DAGLA
Full Name	Diacylglycerol Lipase Alpha
Chromosome	11
Protein Type	Gene
Function	is a membrane-bound enzyme that catalyzes the hydrolysis of diacylglycerol (DAG) to produce 2-arachidonoylglycerol (2-AG), one of the most abundant endocannabinoids in the brain[@zhang2018].
Amino Acids	1042 aa
GeneCards	DAGLA
Human Protein Atlas	DAGLA
N-terminal transmembrane region	Anchors the enzyme to the endoplasmic reticulum membrane
Serine hydrolase domain	Contains the catalytic triad (Ser-Asp-His) essential for enzymatic activity
Lipase motif (GXSXG)	Critical for diacylglycerol hydrolysis
Cerebellum	Highest expression, particularly in Purkinje cells
Basal Ganglia	Striatum, substantia nigra pars compacta, globus pallidus
Hippocampus	CA1-CA3 pyramidal neurons, dentate gyrus granule cells
Cortex	Layer 2/3 pyramidal neurons
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DAGLA — Diacylglycerol Lipase Alpha

gene · 1146 words

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Pathway Diagram

graph TD
    DAGLA["DAGLA"]
    neurodegeneration["neurodegeneration"]
    DAGLA -->|"implicated_in"| neurodegeneration
    style DAGLA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning DAGLA in their description or question text

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