Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Circadian rhythm / glymphatic clearance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Glymphatic Entrainment via Targeted Orexin Recepto | 0.860 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Circadian Glymphatic Rescue Therapy (Melatonin-focused) | 0.712 | neurodegeneration | Sleep disruption as cause and consequenc |
| Circadian-Gated Maresin Biosynthesis Amplification | 0.557 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.860
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.791
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.900 | 0.50 | aortic endothelial cells | proposed | $6,550,000 |
| s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/ | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NPH Glymphatic System Interaction Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep Disruption and Alzheimer's Disease — mechanism and intervention | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Respiratory Network Interaction in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346] | Cénat JM, Blais-Rochette C, Kokou-Kpolou | Psychiatry Res | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576] | Maynard A, McCoach CE, Rotow JK, Harris | Cell | 2020 | 1 |
| The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and [PMID:30962395] | Yang Y, Wu Y, Ma L, Yang Z, Dong Q, Li Q | Plant Cell | 2019 | 1 |
| ALOX12 is required for p53-mediated tumour suppression through a distinct ferrop [PMID:30962574] | Chu B, Kon N, Chen D, Li T, Liu T, Jiang | Nat Cell Biol | 2019 | 1 |
| Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. [PMID:30472260] | Singh NK, Rao GN | Prog Lipid Res | 2019 | 1 |
| An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-rep [PMID:29227475] | Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang | Nat Med | 2018 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Impact of preinterventional plaque composition and eccentricity on late-acquired [PMID:22936019] | Sato T, Kameyama T, Noto T, Nozawa T, In | Coron Artery Dis | 2012 | 1 |
| Pharmacological and bioinformatics analysis reveals the reno-protective mechanis [PMID:41270547] | ["Ruiping L", "Yafeng W", "Liuyun L", "X | Computational biology and chem | 2026 | 0 |
| Hepatic Effects of Etoricoxib in Mice: Integrated Histopathological and Gene Exp [PMID:41901261] | ["Jamous Y", "Alghamdi B", "Jarrar Y", " | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Association of TyG index and [PMID:41757381] | ["Yin Y", "Yang M", "Deng W", "Zheng W"] | Journal of diabetes and metabo | 2026 | 0 |
| Luteolin alleviates ox-LDL-induced endothelial cell inflammation, apoptosis and [PMID:41633065] | ["Yang B", "Zhang H", "Fang S", "Liu Y", | Molecular immunology | 2026 | 0 |
| Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lip [PMID:41794265] | ["Bai D", "Lu J", "Yang H", "Zhou C", "Z | Biochemical pharmacology | 2026 | 0 |
| Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] | ["Xin R", "Zhang J", "Zhang Y", "Dai M", | Free radical biology & medicin | 2026 | 0 |
| Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohyp [PMID:41870323] | ["Zheng Y", "Chen Q", "Guo H", "Zhang Y" | Journal of pineal research | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.83 · 2026-04-06
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning Circadian rhythm / glymphatic clearance in their description or question text
No additional research found