Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cathepsin_D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Neuronal_Ceroid_Lipofuscinosis | deficiency_causes | mechanism | 0.50 |
| aged_brain | reduced_activity_in | mechanism | 0.50 |
| alpha_synuclein_fibrillization | activates | mechanism | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lysosomal Cathepsin-Dependent Tau Clearance | 0.767 | neurodegeneration | View |
| Cathepsin D Replacement to Overcome Lysosomal Protease Defic | 0.434 | proteomics | Quantitative proteomics of the aging syn |
| Cathepsin-Dependent Processing of Pro-Drug Enzymes | 0.400 | neurodegeneration | How does controlled lysosomal membrane p |
Scientific analyses that reference this entity
proteomics | 2026-04-16 | 16 hypotheses Top: 0.591
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Tau, neurodegeneration and Alzheimer's disease. [PMID:21214513] | Unknown | Curr Alzheimer Res | 2010 | 0 |
| TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124] | Unknown | Prog Brain Res | 2008 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Cathepsin_D in their description or question text
No additional research found