gene

CSTB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSTB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

14Outgoing

1Incoming

0Experiments

0Debates

Summary

Cystatin B in EPM1 progressive myoclonus epilepsy

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CSTB
Full Name	Cystatin B
Chromosome	21q22.3
Protein Type	Protease
Function	CSTB is a potent inhibitor of cysteine proteases and serves multiple protective functions in the nervous system:
Primary Expression	Ubiquitous; highest in brain, liver, spleen
Molecular Weight	11 kDa
Amino Acids	98 aa
UniProt ID	P04080
NCBI Gene ID	1476
Ensembl ID	ENSG0000001333
OMIM	607788
GeneCards	CSTB
Human Protein Atlas	CSTB
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis, Epilepsy
Interactions	SOD1
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CSTB — AlphaFold P04080 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CSTB Gene

gene · 1102 words

→

Pathway Diagram

graph TD
    CSTB["CSTB"]
    ALS["ALS"]
    CSTB -->|"interacts_with"| ALS
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CSTB -->|"associated_with"| Amyotrophic_Lateral_Sclerosis
    Neurodegeneration["Neurodegeneration"]
    CSTB -->|"interacts_with"| Neurodegeneration
    Epilepsy["Epilepsy"]
    CSTB -->|"associated_with"| Epilepsy
    SOD1["SOD1"]
    SOD1 -->|"expressed_in"| CSTB
    Spinal_Cord["Spinal Cord"]
    CSTB -->|"expressed_in"| Spinal_Cord
    Neuron["Neuron"]
    CSTB -->|"expressed_in"| Neuron
    neurodegeneration["neurodegeneration"]
    CSTB -->|"implicated_in"| neurodegeneration
    style CSTB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
ALS	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Epilepsy	associated_with	disease	0.65
neurons	expressed_in	cell_type	0.60
ALS	implicated_in	disease	0.60
oxidative stress response	participates_in	pathway	0.60
neurodegeneration	interacts_with	disease	0.60
epilepsy	interacts_with	disease	0.60
SOD1	implicated_in	gene	0.60
SOD1	expressed_in	gene	0.60
SOD1	interacts_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
Spinal Cord	expressed_in	brain_region	0.55

Incoming (1)

Source	Relation	Type	Str
SOD1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CSTB in their description or question text

No additional research found