Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSF1R Inhibition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Microglia | modulates | cell_type | 0.95 |
| Neuroinflammation | modulates | process | 0.90 |
| Glioblastoma Recurrence | inhibits | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF1R Inhibition-Mediated Microglial Replacement as a State | 0.901 | neurodegeneration | How do different microglial subtypes (DA |
| CSF1R Inhibition Reversal Window Depends on Microglia Replac | 0.395 | neurodegeneration | What is the optimal therapeutic window f |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage. [PMID:41645884] | Di Pietro AA, Thomas L, Pasquini LA | J Neurochem | 2026 | 0 |
| Temporal modulation of microglial repopulation attenuates retinal degeneration i [PMID:41690604] | Zhang W, Bian B, Ren C | Neurobiol Dis | 2026 | 0 |
| The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of [PMID:41822299] | Ferreira AFF, Santos-Silva AC, Muratori | Front Aging Neurosci | 2026 | 0 |
| CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model w [PMID:34103079] | ["Lodder Chritica", "Scheyltjens Isabell | Acta neuropathologica communic | 2021 | 0 |
| Don't know what you got till it's gone: microglial depletion and neurodegenerati [PMID:33642360] | ["Graykowski David", "Cudaback Eiron"] | Neural regeneration research | 2021 | 0 |
| Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental T [PMID:32094203] | ["Henry Rebecca J", "Ritzel Rodney M", " | The Journal of neuroscience : | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CSF1R Inhibition in their description or question text
No additional research found