gene

CHTF18

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CHTF18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CTF18 Gene

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🧬 Gene Info

Gene Symbol	CTF18
Full Name	Chromosome Transmission Fidelity 18
Chromosome	7q22.1
Function	CTF18 encodes a subunit of the Ctf18-RFC complex, which loads proliferating cell nuclear antigen (PCNA) onto DNA for replication and repair.
UniProt ID	Q8IY92
NCBI Gene ID	63922
Ensembl ID	ENSG00000132905
OMIM	607196
GeneCards	CTF18
Human Protein Atlas	CTF18
Checkpoint Activation	Recruits ATR/ATM kinases to stalled replication forks
Damage Tolerance	Facilitates template switching and translesion synthesis
Sister Chromatid Cohesion	Establishes cohesion between replicated sister chromatids
Repair Recruitment	Localizes repair proteins to damaged DNA
Genomic Instability	Accumulated DNA damage in neurons
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHTF18 — AlphaFold Q8IY92 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CTF18 Gene

gene · 709 words

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Pathway Diagram

graph TD
    CHTF18["CHTF18"]
    neurodegeneration["neurodegeneration"]
    CHTF18 -->|"implicated_in"| neurodegeneration
    style CHTF18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CHTF18 in their description or question text

No additional research found