| Gene Symbol | CTF18 |
| Full Name | Chromosome Transmission Fidelity 18 |
| Chromosome | 7q22.1 |
| Function | CTF18 encodes a subunit of the Ctf18-RFC complex, which loads proliferating cell nuclear antigen (PCNA) onto DNA for replication and repair. |
| UniProt ID | Q8IY92 |
| NCBI Gene ID | 63922 |
| Ensembl ID | ENSG00000132905 |
| OMIM | 607196 |
| GeneCards | CTF18 |
| Human Protein Atlas | CTF18 |
| Checkpoint Activation | Recruits ATR/ATM kinases to stalled replication forks |
| Damage Tolerance | Facilitates template switching and translesion synthesis |
| Sister Chromatid Cohesion | Establishes cohesion between replicated sister chromatids |
| Repair Recruitment | Localizes repair proteins to damaged DNA |
| Genomic Instability | Accumulated DNA damage in neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!