gene

CHD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CHD3 (Chromodomain Helicase DNA Binding Protein 3)

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🧬 Gene Info

Gene Symbol	CHD3
Full Name	Chromodomain Helicase DNA Binding Protein 3
Chromosome	17q17.1
Protein Type	Enzyme
Function	CHD3 (Chromodomain Helicase DNA Binding Protein 3) encodes a member of the CHD (Chromodomain Helicase DNA-binding) family of chromatin remodelers.
Primary Expression	fetal and adult tissues, with highest expression in brain
UniProt ID	[Q12873](https://www.uniprot.org/uniprot/Q12873)
Ensembl ID	ENSG00000153608
GeneCards	CHD3
Human Protein Atlas	CHD3
Two chromodomains	Methyl-lysine binding modules that recognize histone modifications
SANT domains	DNA-binding and histone-tail interacting domains
Snf2-like ATPase domain	Catalytic core for chromatin remodeling activity
C-terminal domains	Mediate protein-protein interactions within the NuRD complex
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHD3["CHD3"]
    neurodegeneration["neurodegeneration"]
    CHD3 -->|"implicated_in"| neurodegeneration
    style CHD3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CHD3 in their description or question text

No additional research found