Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHCHD9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHCHD9 is a mitochondrial protein involved in oxidative phosphorylation, mitochondrial dynamics, and cellular stress response, with relevance to Parkinson's and Alzheimer's diseases.
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| Gene Symbol | CHCHD9 |
| Full Name | Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 9 |
| Chromosome | 9q34.11 |
| Protein Type | Mitochondrial CHCHD family |
| Function | is a nuclear-encoded mitochondrial protein that plays critical roles in mitochondrial function, oxidative phosphorylation, and cellular stress response. |
| Primary Expression | Brain (cerebral cortex, cerebellum), heart, skeletal muscle |
| UniProt ID | Q8N5L4 |
| NCBI Gene ID | 55033 |
| Ensembl ID | ENSG00000177303 |
| OMIM | 614295 |
| GeneCards | CHCHD9 |
| Human Protein Atlas | CHCHD9 |
| Inner membrane organization | CHCHD9 contributes to maintaining cristae structure and inner membrane integrity |
| Protein complex assembly | Assists in the proper assembly of electron transport chain complexes |
| Mitochondrial dynamics | Regulates fission and fusion processes affecting mitochondrial morphology |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHCHD9["CHCHD9"]
neurodegeneration["neurodegeneration"]
CHCHD9 -->|"implicated_in"| neurodegeneration
style CHCHD9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHCHD9 in their description or question text
No additional research found