gene 1,332 words KG: CHCHD9
Contents

CHCHD9 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 9

🧬 Gene Info
Gene SymbolCHCHD9
Full NameCoiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 9
Chromosome9q34.11
Protein TypeMitochondrial CHCHD family
Functionis a nuclear-encoded mitochondrial protein that plays critical roles in mitochondrial function, oxidative phosphorylation, and cellular stress response.
Primary ExpressionBrain (cerebral cortex, cerebellum), heart, skeletal muscle
UniProt IDQ8N5L4
NCBI Gene ID55033
Ensembl IDENSG00000177303
OMIM614295
GeneCardsCHCHD9
Human Protein AtlasCHCHD9
Inner membrane organizationCHCHD9 contributes to maintaining cristae structure and inner membrane integrity
Protein complex assemblyAssists in the proper assembly of electron transport chain complexes
Mitochondrial dynamicsRegulates fission and fusion processes affecting mitochondrial morphology
DatabasesGeneCardsHPASTRING

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Related Hypotheses (19)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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