concept

CGAS/STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS/STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

2Analyses

15Outgoing

16Incoming

0Experiments

2Debates

No summary available yet.

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💡 Concept Info

Name	CGAS/STING PATHWAY

Pathway Diagram

graph TD
    CGAS_STING_PATHWAY["CGAS/STING PATHWAY"]
    CGAS_STING_PATHWAY -->|"activates"| Type_I_Interferon_Signaling["Type I Interferon Signaling"]
    CGAS_STING_PATHWAY -->|"modulates"| oncogenesis["oncogenesis"]
    CGAS_STING_PATHWAY -->|"involved_in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CGAS_STING_PATHWAY -->|"activates"| ANXA1["ANXA1"]
    CGAS_STING_PATHWAY -->|"modulates"| Immune_Microenvironment["Immune Microenvironment"]
    CGAS_STING_PATHWAY -->|"regulates"| IL_6["IL-6"]
    CGAS_STING_PATHWAY -->|"regulates"| TNF__["TNF-alpha"]
    CGAS_STING_PATHWAY -->|"activates"| microglia["microglia"]
    ANXA1 -->|"inhibits"| CGAS_STING_PATHWAY
    TDP_43["TDP-43"] -->|"activates"| CGAS_STING_PATHWAY
    Loss_of_ANXA1["Loss of ANXA1"] -->|"activates"| CGAS_STING_PATHWAY
    Loss_Of_ANXA1["Loss Of ANXA1"] -->|"activates"| CGAS_STING_PATHWAY
    ANXA1_Deficiency_In_Macrophage["ANXA1 Deficiency In Macrophages"] -->|"activates"| CGAS_STING_PATHWAY
    TDP43["TDP43"] -->|"activates"| CGAS_STING_PATHWAY

Outgoing (15)

Target	Relation	Type	Str
Type I Interferon Signaling	activates	pathway	0.95
Senescence-Related Disorders	involved_in	disease	0.90
Necroptosis	activates	process	0.90
Cancer	involved_in	disease	0.90
oncogenesis	modulates	process	0.88
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.85
Α-Synucleinopathy	associated_with	disease	0.82
Immune Microenvironment	modulates	process	0.80
ANXA1	activates	gene	0.80
Amyotrophic Lateral Sclerosis	involved_in	disease	0.80
neurodegeneration	causes	disease	0.70
IL-6	regulates	protein	0.70
TNF-α	regulates	protein	0.70
microglia	activates	cell_type	0.70
neurodegeneration	causes	disease	0.70

Incoming (16)

Source	Relation	Type	Str
ANXA1	inhibits	protein	0.95
Loss Of ANXA1	activates	phenotype	0.90
ANXA1	regulates	protein	0.90
TDP-43	activates	protein	0.90
Loss of ANXA1	activates	process	0.90
Loss of ANXA1	activates	mechanism	0.90
ANXA1 Deficiency In Macrophages	activates	phenotype	0.88
Tardbp	activates	protein	0.88
TDP43	activates	protein	0.85
ANXA1	regulates	protein	0.85
Hydrogen sulfide	inhibits	compound	0.85
ANXA1	inhibits	gene	0.80
TP53	interacts_with	gene	0.70
IFN-β	amplifies	cytokine	0.70
mtDNA	activates	process	0.70
mitochondrial DNA	activates	biomarker	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

neuroinflammation | 2026-04-07 | 8 hypotheses Top: 0.771

What determines the specificity of TDP-43-induced mitochondrial DNA release for

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CGAS/STING PATHWAY in their description or question text

No additional research found