concept

CGAS/STING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS/STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

3Hypotheses

2Analyses

14Outgoing

5Incoming

0Experiments

2Debates

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💡 Concept Info

Name	CGAS/STING

Pathway Diagram

graph TD
    CGAS_STING[CGAS/STING]
    CGAS_STING -->|activates| type_I_interferon[type I interferon]
    CGAS_STING -->|promotes| antitumor_T_cell_responses[antitumor T cell responses]
    CGAS_STING -->|involved_in| Innate_Immune_Response[Innate Immune Response]
    CGAS_STING -->|regulates| Cellular_Senescence[Cellular Senescence]
    CGAS_STING -->|contributes to| Oncogenesis[Oncogenesis]
    CGAS_STING -->|involved_in| ALS[ALS]
    CGAS_STING -->|modulates| Cancer_Development[Cancer Development]
    CGAS_STING -->|mediates| Cancer_Suppression[Cancer Suppression]
    CGAS_STING -->|contributes to| Amyotrophic_Lateral_Sclerosis[Amyotrophic Lateral Sclerosis]
    endogenous_DNA[endogenous DNA] -->|activates| CGAS_STING
    mitochondrial_DNA[mitochondrial DNA] -->|activates| CGAS_STING
    TARDBP[TARDBP] -->|activates| CGAS_STING
    LRRK2[LRRK2] -->|modulates| CGAS_STING

Outgoing (14)

Target	Relation	Type	Str
Cellular Senescence	regulates	process	0.95
type I interferon	activates	process	0.95
antitumor T cell responses	promotes	process	0.95
Cytosolic DNA	associated_with	compound	0.95
Innate Immune Response	involved_in	process	0.95
type I interferon response	activates	pathway	0.90
Oncogenesis	contributes_to	disease	0.90
neuroinflammation	mediates	mechanism	0.90
ALS	involved_in	disease	0.90
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.85
Cancer Suppression	mediates	process	0.85
Cancer Development	modulates	process	0.85
NF-kB pathway	activates	pathway	0.70
Type I interferon	activates	process	0.70

Incoming (5)

Source	Relation	Type	Str
mitochondrial DNA release	activates	mechanism	0.95
endogenous DNA	activates	process	0.90
mitochondrial DNA	activates	compound	0.90
TARDBP	activates	protein	0.90
LRRK2	modulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific	0.720	neurodegeneration	What determines the specificity of TDP-4
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d
Astrocyte cGAS/STING Activation Converts Protective into Des	0.580	neuroinflammation	How does chronic cGAS/STING activation d