protein

CATHEPSINK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSINK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	CATHEPSINK
Protein Family	Papain family cysteine proteases
Protein Type	Protease
Function	Cathepsin K is unique among the cathepsin family due to its potent collagenolytic activity — it can cleave collagen at neutral pH and even within the triple-helical regions that are typically resis...
Primary Expression	osteoclasts, where it plays the primary role in bone resorption through its exceptional ability to degrade type I and type II collagen at acidic pH[@l
Amino Acids	329 aa
UniProt ID	P43235
GeneCards	CATHEPSINK
Human Protein Atlas	CATHEPSINK
L-domain (left)	Predominantly alpha-helical, comprising residues 115–200
R-domain (right)	Contains the beta-barrel and the catalytic site, residues 201–329
Active site cleft	Separates the two domains, containing the catalytic triad (Cys25, His159, Asn175 in the mature enzyme numbering)
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CATHEPSINK — AlphaFold P43235 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cathepsin K

protein · 2464 words

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Pathway Diagram

graph TD
    CATHEPSINK["CATHEPSINK"]
    neurodegeneration["neurodegeneration"]
    CATHEPSINK -->|"implicated_in"| neurodegeneration
    style CATHEPSINK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CATHEPSINK in their description or question text

No additional research found