| Gene Symbol | CATHEPSINK |
| Protein Family | Papain family cysteine proteases |
| Protein Type | Protease |
| Function | Cathepsin K is unique among the cathepsin family due to its potent collagenolytic activity — it can cleave collagen at neutral pH and even within the triple-helical regions that are typically resis... |
| Primary Expression | osteoclasts, where it plays the primary role in bone resorption through its exceptional ability to degrade type I and type II collagen at acidic pH[@l |
| Amino Acids | 329 aa |
| UniProt ID | P43235 |
| GeneCards | CATHEPSINK |
| Human Protein Atlas | CATHEPSINK |
| L-domain (left) | Predominantly alpha-helical, comprising residues 115–200 |
| R-domain (right) | Contains the beta-barrel and the catalytic site, residues 201–329 |
| Active site cleft | Separates the two domains, containing the catalytic triad (Cys25, His159, Asn175 in the mature enzyme numbering) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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