protein

CASRPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASRPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

The Calcium-Sensing Receptor (CASR) is a class C G protein-coupled receptor (GPCR) that functions as the principal molecular sensor of extracellular calcium concentrations in the body.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	CASRPROTEIN
Full Name	Calcium-Sensing Receptor Protein
Protein Family	C family (Class C GPCR), Metabotrophic glutamate receptor family
Protein Type	Receptor
Function	is a class C G protein-coupled receptor (GPCR) that functions as the principal molecular sensor of extracellular calcium concentrations in the body.
Primary Expression	Brain (hippocampus, cerebellum, cortex, substantia nigra), parathyroid, kidney, pancreas
Molecular Weight	120 kDa (monomer), functional dimers ~240 kDa
UniProt ID	Q9UII2
GeneCards	CASRPROTEIN
Human Protein Atlas	CASRPROTEIN
N-linked glycosylation	Multiple N-glycosylation sites in the extracellular domain affect receptor folding, trafficking, and function
Disulfide bond formation	Conserved cysteine residues form intramolecular disulfide bonds essential for structural integrity
Phosphorylation	Serine and threonine residues in the C-terminal tail are phosphorylated by multiple kinases, regulating desensitization and signaling
Palmitoylation	Cysteine residues near the C-terminus can be palmitoylated, affecting membrane localization
Associated Diseases	Parkinson's Disease
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CASRPROTEIN — AlphaFold Q9UII2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calcium-Sensing Receptor Protein

protein · 2107 words

→

Pathway Diagram

graph TD
    CASRPROTEIN["CASRPROTEIN"]
    neurodegeneration["neurodegeneration"]
    CASRPROTEIN -->|"implicated_in"| neurodegeneration
    style CASRPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASRPROTEIN in their description or question text

No additional research found