| Gene Symbol | CASRPROTEIN |
| Full Name | Calcium-Sensing Receptor Protein |
| Protein Family | C family (Class C GPCR), Metabotrophic glutamate receptor family |
| Protein Type | Receptor |
| Function | is a class C G protein-coupled receptor (GPCR) that functions as the principal molecular sensor of extracellular calcium concentrations in the body. |
| Primary Expression | Brain (hippocampus, cerebellum, cortex, substantia nigra), parathyroid, kidney, pancreas |
| Molecular Weight | 120 kDa (monomer), functional dimers ~240 kDa |
| UniProt ID | Q9UII2 |
| GeneCards | CASRPROTEIN |
| Human Protein Atlas | CASRPROTEIN |
| N-linked glycosylation | Multiple N-glycosylation sites in the extracellular domain affect receptor folding, trafficking, and function |
| Disulfide bond formation | Conserved cysteine residues form intramolecular disulfide bonds essential for structural integrity |
| Phosphorylation | Serine and threonine residues in the C-terminal tail are phosphorylated by multiple kinases, regulating desensitization and signaling |
| Palmitoylation | Cysteine residues near the C-terminus can be palmitoylated, affecting membrane localization |
| Associated Diseases | Parkinson's Disease |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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