protein

CASP7PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP7PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Caspase-7 is an executioner caspase in the caspase family of cysteine proteases that plays a central role in programmed cell death (apoptosis).

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🔬 Protein Info

Gene Symbol	CASP7PROTEIN
Protein Type	Protease
Function	is an executioner caspase in the caspase family of cysteine proteases that plays a central role in programmed cell death (apoptosis).
Subcellular Localization	</strong> Cytoplasm, cytoskeleton</div> <div class="infobox-row"><strong>Protein
Molecular Weight	35 kDa
Amino Acids	23 aa
GeneCards	CASP7PROTEIN
Human Protein Atlas	CASP7PROTEIN
Pro-domain	Contains a short N-terminal prodomain (~23 amino acids)
Large subunit (p20)	Contains the catalytic cysteine residue
Small subunit (p12)	Completes the active site formation
Active form	The heterotetrameric active caspase-7 consists of two p20/p12 heterodimers
Catalytic dyad	His237 and Cys277 form the catalytic dyad essential for protease activity
Substrate-binding pocket	Recognizes the DEVD tetrapeptide sequence (caspase-7 preferred cleavage site)
Tau cleavage	Caspase-7 cleaves tau protein, generating toxic fragments that may propagate pathology
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-7 Protein

protein · 710 words

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Pathway Diagram

graph TD
    CASP7PROTEIN["CASP7PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CASP7PROTEIN -->|"implicated_in"| neurodegeneration
    style CASP7PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CASP7PROTEIN in their description or question text

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