| Gene Symbol | CASP7PROTEIN |
| Protein Type | Protease |
| Function | is an executioner caspase in the caspase family of cysteine proteases that plays a central role in programmed cell death (apoptosis). |
| Subcellular Localization | </strong> Cytoplasm, cytoskeleton</div> <div class="infobox-row"><strong>Protein |
| Molecular Weight | 35 kDa |
| Amino Acids | 23 aa |
| GeneCards | CASP7PROTEIN |
| Human Protein Atlas | CASP7PROTEIN |
| Pro-domain | Contains a short N-terminal prodomain (~23 amino acids) |
| Large subunit (p20) | Contains the catalytic cysteine residue |
| Small subunit (p12) | Completes the active site formation |
| Active form | The heterotetrameric active caspase-7 consists of two p20/p12 heterodimers |
| Catalytic dyad | His237 and Cys277 form the catalytic dyad essential for protease activity |
| Substrate-binding pocket | Recognizes the DEVD tetrapeptide sequence (caspase-7 preferred cleavage site) |
| Tau cleavage | Caspase-7 cleaves tau protein, generating toxic fragments that may propagate pathology |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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