gene

CASP10

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CASP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Caspase-10 gene involved in apoptosis, necroptosis, and immune regulation with implications for Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	CASP10
Chromosome	2q33.3
Function	is an initiator caspase that transduces death signals from cell surface receptors to the intracellular cell death machinery[@caspase2020].
Amino Acids	521 aa
Ensembl ID	ENSG00000127334
GeneCards	CASP10
Human Protein Atlas	CASP10
Pro-apoptotic	In some contexts, CASP10 can initiate apoptosis through the extrinsic pathway
Anti-apoptotic	CASP10 can also inhibit necroptosis by cleaving key necroptotic proteins, particularly when CASP8 is deficient[@necroptosis2023]
Neuronal Apoptosis	CASP10 is activated by amyloid-beta (Aβ) toxicity through death receptor pathways, leading to synaptic loss and neuronal death.
Tau Pathology	CASP10 can cleave tau protein, generating truncated fragments that may promote neurofibrillary tangle formation.
Neuroinflammation	CASP10 participates in inflammatory signaling cascades involving NF-κB, amplifying microglial activation and cytokine production[@nfkb2022].
Synaptic Dysfunction	CASP10 activation contributes to the loss of synaptic proteins including PSD-95 and synaptophysin, correlating with cognitive decline[@synaptic2018].
α-Synuclein Toxicity	Oligomeric α-synuclein activates death receptors, recruiting CASP10 to initiate apoptosis.
Oxidative Stress	Increased reactive oxygen species (ROS) sensitize neurons to death receptor signaling.
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CASP10 Gene

gene · 1752 words

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Pathway Diagram

graph TD
    CASP10["CASP10"]
    neurodegeneration["neurodegeneration"]
    CASP10 -->|"implicated_in"| neurodegeneration
    style CASP10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CASP10 in their description or question text

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