gene

CA8

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CA8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CA8 gene page for Carbonic Anhydrase VIII

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🧬 Gene Info

Gene Symbol	CA8
Full Name	Carbonic Anhydrase VIII
Chromosome	9
Function	encodes a member of the alpha-carbonic anhydrase family of zinc metalloenzymes.
Subcellular Localization	CA8 is primarily localized in the cytoplasm, with some association with the plasma membrane. Importantly, CA8 shows part
Amino Acids	290 aa
Exons	7
Ensembl ID	ENSG00000168259
GeneCards	CA8
Human Protein Atlas	CA8
Zinc-binding site	Substituted with alanine and glycine residues
Proton shuttle	Replaced by hydrophobic amino acids
Surface loops	Modified to create protein-protein interaction interfaces
Cerebellum	Highest expression in Purkinje cells
Cerebral cortex	Moderate expression in pyramidal neurons
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CA8 Gene - Carbonic Anhydrase VIII

gene · 2523 words

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Pathway Diagram

graph TD
    CA8["CA8"]
    neurodegeneration["neurodegeneration"]
    CA8 -->|"implicated_in"| neurodegeneration
    style CA8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CA8 in their description or question text

No additional research found